NGAL Rapid ELISA Kit (IVD)
NGAL - An Early Marker of Kidney Injury
NGAL (neutrophil gelatinase-associated lipocalin, also known as lipocalin-2) is a small protein found not only in neutrophils but also in certain epithelia, such as renal tubules, where its expression is dramatically increased in ischemic or nephrotoxic injury. NGAL levels rise in urine and blood within 2 hours of renal injury. This makes NGAL an early, sensitive and non-invasive biomarker for acute renal injury.
NGAL levels above those normally seen in infections indicate acute renal injury which may lead to acute renal failure. NGAL determination is relevant in connection with:
Up to 50% of patients in intensive care may suffer some degree of acute renal failure. The onset of acute renal failure on top of other critical illness increases mortality dramatically. The prognosis of acute renal failure has not improved significantly over the last four decades. Current diagnostic methods such as serum creatinine or cystatin C measurements only respond after renal function has deteriorated, which may only become apparent one or more days after the original insult. With the NGAL Rapid ELISA Kit, physicians can initiate appropriate management of acute renal failure within hours rather than days of the insult. NGAL levels rise rapidly after renal injury. The mean NGAL concentration in plasma from healthy donors was 63 ng/mL (range 37â€“106 ng/mL). In unselected patients admitted to intensive care, the NGAL concentrations in urine ranged from 110 ng/mL to 40,000 ng/mL. Urinary levels above a cutoff of 350 ng/mL are associated with acute renal failure, while levels above 2000 ng/mL are predictive of dialysis requirement.
Illustrative time-course of urinary NGAL concentration after a moderate renal insult.
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